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24, chemin de Borde Rouge -Auzeville - CS52627 31326 Castanet Tolosan cedex - France

Last update: May 2021

Menu Logo Principal UB AgroSup CNRS



Chargé de recherche CNRS, section 23
Pôle : IPM
Equipe/Thème : Immunité et signalisation
Courriel :
Tel :

Curriculum Vitae

depuis 2008 : Chargé de recherche, CNRS, UMR Agroécologie, Dijon2005-2008 : Postdoctorat, laboratoire de biologie végétale, université de Fribourg, Suisse (Pr. J-P Métraux)2001-2004 : Doctorat de biochimie, biologie moléculaire et cellulaire, Université de Bourgogne, Dijon, France2001 : DEA de biochimie, biologie moléculaire et cellulaire, Université de Bourgogne, Dijon, France


Activités de Recherche

Mes activités de recherche concernent le rôle des processus red−ox dans les réponses de défense des plantes. Je m'intéresse à l'importance du NO dans les voies de signalisation cellulaire qui conduisent à ces défenses. J'étudie en particulier le rôle des protéines modifiées par le NO sur leurs fonctions thiol (S-nitrosation). Je m’attache également à comprendre le rôle des voies UPR (unfolded protein response) chez les plantes lors d'infections par des pathogènes. Dans le contexte des interactions plantes micro-organismes, j’étudie l'impact des champignons mycorhiziens sur des portes−greffes de noyers dans le cadre d'un co−encadrement de thèse. Une autre partie de mon activité concerne l’étude de l’effet des pesticides sur des organismes non-cibles. Elle est réalisée en collaboration avec une équipe de l'unité INSERM 1231 de Dijon. Activités d’enseignement (Teaching) : (10 lignes maximum)En tant que chercheur au CNRS, je participe à l’enseignement à l’Université de Bourgogne notamment :(1) dans le cadre de la licence professionnelle Parcours Culture de Tissus et de Cellules et Biologie Moléculaire (CTCBM) à l’IUT de Dijon ( Je m’occupe du l’UE  "biotechnologies vertes (cours et travaux pratiques)"(2) dans le cadre de la licence de Biologie. Je participe à l’enseignement dans l’option "biotechnologies vertes » en 3ème année (cours et travaux pratiques)(3) dans le cadre du Master 1 "Vigne, Vin, Terroirs" à l’institut Universitaire de la vigne et du vin Jules-Guyot. Je participe au travaux pratiques dans l’UE "Nutrition carbonée et métabolisme de la vigne". 



31. Teyssier L., Sorci G., Chluba J., Aimé S., Wendehenne D., Lamotte O. and Connat JL. (2020) Some Plant Defense Stimulators can induce IL-1β production in human immune cells in vitro. Toxicology Reports 7:413-420.

30. Aimé S., Hichami S., Wendehenne D. and Lamotte O.* (2018) Analysis of Recombinant Protein S-Nitrosylation Using the Biotin-Switch Technique. Methods Mol Biol. 1747:131-141. doi: 10.1007/978-1-4939-7695-9_11. (*corresponding author)

29. Nicolas-Francès V., Grandperret V., Liegard B., Jeandroz S., Vasselon D., Aimé S., Klinguer A., Lamotte O., Julio E., Dorlhac de Borne F., Wendehenne D. and Bourque S. (2018) Evolutionary diversification of type-2 HDAC structure, function and regulation in Nicotiana tabacum. Plant Science 269:66-74. doi: 10.1016/j.plantsci.2018.01.007.

28.  Jeandroz S. and Lamotte O*. (2017) Editorial : Plant responses to biotic and abiotic stresses: lessons from cell signaling. Front. Plant Sci. doi: 10.3389/fpls.2017.01772 (*corresponding author)

27. Teyssier L., Colussi J., Delemasure S., Chluba J., Wendehenne D., Lamotte O*. and Connat J.-L*. (2017) Inflammatory Effects of the Plant Protection Product Stifenia (FEN560) on Vertebrates. Front. Public Health 5:74. doi: 10.3389/fpubh.2017.00074 (*corresponding author)

26. Claverie J., Teyssier L., Héloir M.-C., Connat J.-L., Lamotte O.* and Poinssot B.* (2016) Les plantes possèdent un système immunitaire efficace pour lutter contre les infections bactériennes Med Sci (Paris) 32 : 335-339. doi: 10.1051/medsci/20163204008 (*corresponding author)

25. Lamotte O., Bertoldo J.B., Besson-Bard A., Rosnoblet C, Aimé S., Hichami S., Terenzi H. and Wendehenne D. (2015) Protein S-nitrosylation: specificity and identification strategies in plants. Front Chem. doi: 10.3389/fchem.2014.00114 

24. Trapet P., Kulik A., Lamotte O., Jeandroz S., Bourque S., Nicolas-Francès V., Rosnoblet C., Besson-Bard A., Wendehenne D. (2015) NO signaling in plant immunity: A tale of messengers. Phytochemistry 112 : 72-79. doi: 10.1016/j.phytochem.2014.03.015

23. Jeandroz S., Lamotte O., Astier J., Rasul S., Trapet P., Besson-Bard A., Bourque S., Nicolas-Frances V., Wei M.,  Berkowitz G., and Wendehenne D. (2013) There's more to the picture than meets the eye: Nitric oxide cross-talk with Ca2+ signaling. Plant Physiol. 163 : 459-470. doi: 10.1104/pp.113.220624

22. Koen E., Besson-Bard A., Duc C., Astier J., Gravot A., Richaud P., Lamotte O., Boucherez J., Gaymard F., Wendehenne D. (2013) Arabidopsis thaliana nicotianamine synthase 4 is required for proper response to iron deficiency and to cadmium exposure. Plant Sci. 209 : 1-11. doi: 10.1016/j.plantsci.2013.04.006

21. Koen E., Lamotte O., Besson-Bard A., Bourque S., Nicolas-Frances V., Jeandroz S., and Wendehenne D. (2013) Nitric oxide is a major player in plant immune system. Méd. Sci. 29 : 309-316. doi: 10.1051/medsci/2013293018

20. Doidy J., van Tuinen D., Lamotte O., Corneillat M., Alcaraz G., and Wipf D (2012) The Medicago truncatula sucrose transporter family. Characterization and implication of key members in carbon partitioning towards arbuscular mycorrhizal fungi. Mol. Plant, 5 : 1346-1358. doi: 10.1093/mp/sss079

19. Astier J., Besson-Bard A., Lamotte O., Bourque S., Bertoldo J., Terenzi H. and Wendehenne D. (2012) NO inhibits the ATPase activity of the chaperone-like AAA+ATPase CDC48, a target for S- nitrosylation in cryptogein signaling in tobacco cells, Biochem. J., 5 : 1346-1358. DOI: 10.1042/BJ20120257

18. Astier J., Kulik A., Koen E., Besson-Bard A., Bourque S., Jeandroz S., Lamotte O. and  Wendehenne D. (2012) Protein S-nitrosylation: What's going on in plants? Free Radic. Biol. Med.,53 : 1101-1110. doi: 10.1016/j.freeradbiomed.2012.06.032

17. Rasul S., Dubreuil-Maurizi C., Lamotte O., Koen E., Poinssot B., Alcaraz G., Wendehenne D. and Jeandroz S. (2012) Nitric oxide production mediates oligogalacturonides-triggered immunity and resistance to Botrytis cinerea in Arabidopsis thaliana. Plant Cell Environ., 35 : 1483-1499.

16. La Camera S., L'Haridon F., Astier J., Zander M., Abou-Mansour E., Page G., Thurow C., Wendehenne D., Gatz C, Métraux J-P. and Lamotte O*. (2011) The glutaredoxin ATGRXS13 is required for Arabidopsis susceptibility to the necrotrophic fungus Botrytis cinerea. Plant J., 68, 507-519. doi: 10.1111/j.1365-313X.2011.04706.x (*corresponding author)

15. L'Haridon F., Besson-Bard A., Binda M., Serrano M., Abou-Mansour E., Balet F., Schoonbeek H-J., Hess S., Mir R., Léon J., Lamotte O. and Métraux J-P. (2011) A permeable cuticle is associated with the release of reactive oxygen species and induction of innate immunity. PLoS Pathog., 7(7):e1002148. doi: 10.1371/journal.ppat.1002148.

14. Astier J., Rasul S., Koen E., Manzoor H., Besson-Bard A., Lamotte O., Jeandroz S., Durner J., Lindermayr C. and Wendehenne D. (2011) S-nitrosylation: an emerging post-translational protein modification in plants. Plant Sci., 181: 527-533. doi: 10.1016/j.plantsci.2011.02.011

13.Mazars C., Thuleau P., Lamotte O. and Bourque S. (2010) Cross-talk between ROS and calcium in regulation of nuclear activities. Mol. Plant, 3 : 706-718. doi: 10.1093/mp/ssq024

12. Zander M. , La Camera S., Lamotte O., Métraux J.-P. And Gatz C. (2010) Arabidopsis thaliana class- II TGA transcription factors are essential activators of jasmonic acid/ethylene-induced defense responses. Plant J., 61 : 200-210. doi: 10.1111/j.1365-313X.2009.04044.x

11. Chassot C., Buchala A., Schoonbeek H.-J., Métraux J.-P. and Lamotte O.* (2008) Wounding causes a powerful but transient protection against a major plant pathogen. Plant J., 55 : 555-567. doi: 10.1111/j.1365-313X.2008.03540.x. (*corresponding author)

10. Gauthier A., Lamotte O., Reboutier D., Bouteau F., Pugin A. and Wendehenne D. (2007) Cryptogein-induced anion effluxes : electrophysiological properties and analysis of the mechanisms through which they contribute to the elicitor-triggered cell death, Plant Signal. Behav., 2 : 86-95. PMID: 19516973

9. Garcia-Brugger A., Lamotte O., Vandelle C., Bourque S., Lecourieux D., Poinsot B., Wendehenne D. and Pugin A. (2006) Signaling pathways activated by elicitors of plant defenses. Mol. Plant Microbe Interact., 19 : 711-724. DOI:10.1094/MPMI-19-0711

8. Lamotte O., Courtois C., Dobrowolska G., Besson A., Pugin A. and Wendehenne D. (2006) Mechanisms of nitric oxide-induced increase of free cytosolic Ca2+ concentration in Nicotiana plumbaginifolia cells. Free Radic. Biol. Med., 40 : 1369-1376.  DOI :10.1016/j.freeradbiomed.2005.12.006

7. Wendehenne D., Gould K., Lamotte O., Durner J., Vandelle E., Lecourieux D., Courtois C., Barnavon L., Bentéjac M. and Pugin A. (2005) NO signaling functions in the biotic and abiotic stress responses. BMC Plant Biology 5 (Suppl 1) :S35

6. Lecourieux D., Lamotte O., Bourque S., Wendehenne D., Mazars C., Ranjeva R. and Pugin A. (2005) Proteinaceous and oligosaccharidic elicitors induce different calcium signatures in the nuclear of tobacco cells. Cell Calcium, 38 : 527-538. DOI:10.1016/j.ceca.2005.06.036

5. Lamotte O., Courtois C., Barnavon L., Pugin, A. and Wendehenne D. (2005) Nitric oxide in plants : the biosynthesis and cell signaling properties of a fascinating molecule. Planta, 221 : 1-4.

4. Lamotte O., Gould K., Lecourieux D., Sequeira-Legrand A., Klinguer A., Lebrun-Garcia A., Durner J., Pugin A. and Wendehenne D. (2004) Analysis of nitric oxide signaling functions in tobacco cells challenged by the proteinaceous elicitor cryptogein. Plant Physiol., 135 : 516-529. DOI: 10.1104/pp.104.038968

3. Gould K., Lamotte O., Klinguer A., Pugin A. and Wendehenne D. (2003) Nitric oxide production by tobacco leaves : a general stress responses? Plant cell environ., 26 : 1851-1862.

2. Wendehenne D., Lamotte O. and Pugin A. (2003) Plant iNOS : conquest of the Holy Grail. Trends Plant Sci., 8 : 465-468. DOI: 10.1016/j.tplants.2003.09.003

1. Wendehenne D., Lamotte O., Frachisse J-M., Barbier-Brygoo H. and Pugin A. (2002) Nitrate efflux is an essential component of the cryptogein signalling pathway leading to defense responses and hypersensitive cell death in tobacco. Plant Cell., 14 : 1937-1951. DOI:


Mots clés

plant pathogen interaction, nitric oxide, toxicology, UPR, Botrytis, Arabidopsis thaliana