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INRA
24, chemin de Borde Rouge –Auzeville – CS52627
31326 Castanet Tolosan CEDEX - France

Dernière mise à jour : Mai 2018

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LESIGNOR Christine

LESIGNOR Christine
Ingénieur de Recherche INRAE
Pôle : GEAPSI
Equipe/Thème : Remplissage de la graine, remobilisation NS, et stress abiotiques de fin de cycle
Courriel : christine.lesignor@inrae.fr
Tel : 03.80.69.31.47
Fax : 03.80.69.32.63

Curriculum Vitae

2000  à aujourd’hui : IR1 à UMR AgroEcologie Dijon, Pôle GEAPSI, Equipe FILEAS
1992 : IR2 à  UMR Génétique Quantitative et Évolution-Le Moulon
1992 : Doctorat en génétique et amélioration des plantes INAPG
1989-1992 : Stage doctoral au GAFL, Unité de Recherche en Génétique et Amélioration des Fruits & Légumes, Montfavet.
1989 : Ingénieur agronome Ecole Nationale Supérieure d’Agronomie de Montpellier.

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Activités de Recherche

Dans l’équipe FILEAS (Seed FIlling & Abiotic Stresses) nos recherches sont centrées sur l’amélioration et la stabilisation de la qualité des graines de légumineuses protéagineuses comme le pois en prenant en compte, dans le contexte actuel de changement climatique et de diminution des dépôts de soufre atmosphérique , le stress hydrique et la carence en soufre. Mon travail consiste en la coordination de projets de génétique inverse et de génétique d’association à l’échelle du génome. J’ai mis en place et assure la maintenance de populations de mutants EMS chez la légumineuse modèle, Medicago truncatula et chez le pois de printemps (var. Caméor) et d’hiver (Hr336/11). A partir de ces lignées nous avons pu valider la fonction de plusieurs gènes d’intérêt impliqués dans la qualité et la composition protéique des graines. L’autre volet de mes recherches consiste en l’exploitation de la variabilité génétique naturelle pour mettre en évidence des loci (approche GWAS) impliqués dans la plasticité de la composition protéique des graines en réponse à l’environnement.

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Activités d'enseignement

6h de TD/TP pour le M2 « Biologie Intégrative des Interactions Plante-Microbe-Environnement » de l’Université de Bourgogne-Franche Comté.

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Publications

Guinot F, Szafranski M, Chiquet J, Zancarini A, Le Signor C, Mougel C, Ambroise C. Fast computation of genome-metagenome interaction effects.Algorithms Mol Biol. 2020 Jul 1;15:13. doi: 10.1186/s13015-020-00173-2. PMID:32625242; PMCID: PMC7329492.

Tan S, Sanchez M, Laffont C, Boivin S, Le Signor C, Thompson R, Frugier F, Brault M. A Cytokinin Signaling Type-B Response Regulator Transcription Factor Acting in Early Nodulation. Plant Physiol. 2020 Jul;183(3):1319-1330. doi:10.1104/pp.19.01383. Epub 2020 May 6. PMID: 32376762; PMCID: PMC7333713.

Gallardo K, Besson A, Klein A, Le Signor C, Aubert G, Henriet C, Térézol M, Pateyron S, Sanchez M, Trouverie J, Avice JC, Larmure A, Salon C, Balzergue S, Burstin J. Transcriptional Reprogramming of Pea Leaves at Early Reproductive Stages. Front Plant Sci. 2019 Aug 7;10:1014. doi: 10.3389/fpls.2019.01014. PMID:31440268; PMCID: PMC6693388.

Gibelin-Viala C, Amblard E, Puech-Pages V, Bonhomme M, Garcia M, Bascaules-Bedin A, Fliegmann J, Wen J, Mysore KS, le Signor C, Jacquet C, Gough C. The Medicago truncatula LysM receptor-like kinase LYK9 plays a dual role in immunity and the arbuscular mycorrhizal symbiosis. New Phytol. 2019 Aug;223(3):1516-1529. doi: 10.1111/nph.15891. Epub 2019 Jun 4. PMID: 31058335.

Le Signor C, Vernoud V, Noguero M, Gallardo K, Thompson RD. Functional Genomics and Seed development in Medicago truncatula: An Overview. Methods Mol Biol. 2018; 1822:175-195. doi: 10.1007/978-1-4939-8633-0_13. PMID: 30043305.

Sánchez M, Le Signor C, Aubert G, Darchy B, Gallardo K, Thompson RD. Targeting Induced Local Lesions IN Genomes (TILLING) in Medicago truncatula. Methods Mol Biol. 2018; 1822:71-82. doi: 10.1007/978-1-4939-8633-0_5. PMID:30043297.

Kirienko AN, Porozov YB, Malkov NV, Akhtemova GA, Le Signor C, Thompson R, Saffray C, Dalmais M, Bendahmane A, Tikhonovich IA, Dolgikh EA. Role of a receptor-like kinase K1 in pea Rhizobium symbiosis development. Planta. 2018 Nov;248(5):1101-1120. doi: 10.1007/s00425-018-2944-4. Epub 2018 Jul 24. PMID: 30043288.

Le Signor C, Aimé D, Bordat A, Belghazi M, Labas V, Gouzy J, Young ND, Prosperi JM, Leprince O, Thompson RD, Buitink J, Burstin J, Gallardo K. Genome- wide association studies with proteomics data reveal genes important for synthesis, transport and packaging of globulins in legume seeds. New Phytol. 2017 Jun;214(4):1597-1613. doi: 10.1111/nph.14500. Epub 2017 Mar 21. PMID:28322451.

Zinsmeister J, Lalanne D, Terrasson E, Chatelain E, Vandecasteele C, Vu BL, Dubois-Laurent C, Geoffriau E, Signor CL, Dalmais M, Gutbrod K, Dörmann P, Gallardo K, Bendahmane A, Buitink J, Leprince O. ABI5 Is a Regulator of Seed Maturation and Longevity in Legumes. Plant Cell. 2016 Nov;28(11):2735-2754. doi: 10.1105/tpc.16.00470. Epub 2016 Nov 15. PMID: 27956585; PMCID: PMC5155344.

Vernié T, Camut S, Camps C, Rembliere C, de Carvalho-Niebel F, Mbengue M, Timmers T, Gasciolli V, Thompson R, le Signor C, Lefebvre B, Cullimore J, Hervé C. PUB1 Interacts with the Receptor Kinase DMI2 and Negatively Regulates Rhizobial and Arbuscular Mycorrhizal Symbioses through Its Ubiquitination Activity in Medicago truncatula. Plant Physiol. 2016 Apr;170(4):2312-24. doi:10.1104/pp.15.01694. Epub 2016 Feb 2. PMID: 26839127; PMCID: PMC4825150.

Bell A, Moreau C, Chinoy C, Spanner R, Dalmais M, Le Signor C, Bendahmane A, Klenell M, Domoney C. SGRL can regulate chlorophyll metabolism and contributes to normal plant growth and development in Pisum sativum L. Plant Mol Biol. 2015 Dec;89(6):539-58. doi: 10.1007/s11103-015-0372-4. Epub 2015 Sep 7. PMID:26346777; PMCID: PMC4659853.

Clemente A, Arques MC, Dalmais M, Le Signor C, Chinoy C, Olias R, Rayner T, Isaac PG, Lawson DM, Bendahmane A, Domoney C. Correction: Eliminating Anti-Nutritional Plant Food Proteins: The Case of Seed Protease Inhibitors in Pea.PLoS One. 2015 Sep 4;10(9):e0138039. doi: 10.1371/journal.pone.0138039. Erratumfor: PLoS One. 2015;10(8):e0134634. PMID: 26340668; PMCID: PMC4560452.

 Noguero M, Le Signor C, Vernoud V, Bandyopadhyay K, Sanchez M, Fu C, Torres-Jerez I, Wen J, Mysore KS, Gallardo K, Udvardi M, Thompson R, Verdier J. DASH transcription factor impacts Medicago truncatula seed size by its action on embryo morphogenesis and auxin homeostasis. Plant J. 2015 Feb;81(3):453-66. doi:10.1111/tpj.12742. PMID: 25492260; PMCID: PMC4329604.

Gallardo K, Courty PE, Le Signor C, Wipf D, Vernoud V. Sulfate transporters in the plant's response to drought and salinity: regulation and possible functions. Front Plant Sci. 2014 Oct 29;5:580. doi: 10.3389/fpls.2014.00580. PMID: 25400648; PMCID: PMC4212607.

Zuber H, Poignavent G, Le Signor C, Aimé D, Vieren E, Tadla C, Lugan R, Belghazi M, Labas V, Santoni AL, Wipf D, Buitink J, Avice JC, Salon C, Gallardo K. Legume adaptation to sulfur deficiency revealed by comparing nutrient allocation and seed traits in Medicago truncatula. Plant J. 2013 Dec;76(6):982-96. doi: 10.1111/tpj.12350. Epub 2013 Nov 12. PMID: 24118112.

Tivendale ND, Davidson SE, Davies NW, Smith JA, Dalmais M, Bendahmane AI, Quittenden LJ, Sutton L, Bala RK, Le Signor C, Thompson R, Horne J, Reid JB, Ross JJ. Biosynthesis of the halogenated auxin, 4-chloroindole-3-acetic acid. Plant Physiol. 2012 Jul;159(3):1055-63. doi: 10.1104/pp.112.198457. Epub 2012 May 9. PMID: 22573801; PMCID: PMC3387693.

Braun N, de Saint Germain A, Pillot JP, Boutet-Mercey S, Dalmais M, Antoniadi I, Li X, Maia-Grondard A, Le Signor C, Bouteiller N, Luo D, Bendahmane A, Turnbull C, Rameau C. The pea TCP transcription factor PsBRC1 acts downstream of Strigolactones to control shoot branching. Plant Physiol. 2012 Jan;158(1):225-38. doi: 10.1104/pp.111.182725. Epub 2011 Nov 1. PMID: 22045922; PMCID: PMC3252107.

Plet J, Wasson A, Ariel F, Le Signor C, Baker D, Mathesius U, Crespi M, Frugier F. MtCRE1-dependent cytokinin signaling integrates bacterial and plant cues to coordinate symbiotic nodule organogenesis in Medicago truncatula. Plant J. 2011 Feb;65(4):622-33. doi: 10.1111/j.1365-313X.2010.04447.x. Epub 2011 Jan 18. PMID: 21244535.

Le Signor C, Savois V, Aubert G, Verdier J, Nicolas M, Pagny G, Moussy F, Sanchez M, Baker D, Clarke J, Thompson R. Optimizing TILLING populations for reverse genetics in Medicago truncatula. Plant Biotechnol J. 2009 Jun;7(5):430-41. doi: 10.1111/j.1467-7652.2009.00410.x. PMID: 19490506.

Morandi D, le Signor C, Gianinazzi-Pearson V, Duc G. A Medicago truncatula mutant hyper-responsive to mycorrhiza and defective for nodulation. Mycorrhiza. 2009 Aug;19(6):435-441. doi: 10.1007/s00572-009-0242-5. Epub 2009 Apr 4. PMID:19347373.

Hofer J, Turner L, Moreau C, Ambrose M, Isaac P, Butcher S, Weller J, Dupin A, Dalmais M, Le Signor C, Bendahmane A, Ellis N. Tendril-less regulates tendril formation in pea leaves. Plant Cell. 2009 Feb;21(2):420-8. doi:10.1105/tpc.108.064071. Epub 2009 Feb 10. PMID: 19208900; PMCID: PMC2660626.

Verdier J, Kakar K, Gallardo K, Le Signor C, Aubert G, Schlereth A, Town CD, Udvardi MK, Thompson RD. Gene expression profiling of M. truncatula transcription factors identifies putative regulators of grain legume seed filling. Plant Mol Biol. 2008 Aug;67(6):567-80. doi: 10.1007/s11103-008-9320-x. Epub 2008 Jun 5. PMID: 18528765.

Triques K, Piednoir E, Dalmais M, Schmidt J, Le Signor C, Sharkey M, Caboche M, Sturbois B, Bendahmane A. Mutation detection using ENDO1: application to disease diagnostics in humans and TILLING and Eco-TILLING in plants. BMC Mol Biol. 2008 Apr 23;9:42. doi: 10.1186/1471-2199-9-42. PMID: 18433472; PMCID:PMC2386800.

Dalmais M, Schmidt J, Le Signor C, Moussy F, Burstin J, Savois V, Aubert G, Brunaud V, de Oliveira Y, Guichard C, Thompson R, Bendahmane A. UTILLdb, a Pisum sativum in silico forward and reverse genetics tool. Genome Biol. 2008;9(2):R43. doi: 10.1186/gb-2008-9-2-r43. Epub 2008 Feb 26. PMID: 18302733; PMCID: PMC2374714.

Principaux contrats :

ANR PEAVALUE 2020-2024                                                                                                                                          
ANR REGULEG 2016-2020   
IA PEAMUST  2012-2020                                                                                                                          
H2020 EUCLEG 2017-2021

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Liens

http://tools.ips2.u-psud.fr/UTILLdb

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Mots clés

Medicago truncatula, pois, graine, composition protéique, mutants, TILLING, GWAS, génétique quantitative

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